Stroke, chiitiko chinoparadza chinoratidzwa nekudzikiswa kamwe kamwe kweropa kuropa rehuropi nekuda kwehemorrhagic kana ischemic pathology, ndicho chikonzero chechipiri cherufu pasi rose uye chechitatu chinotungamira chikonzero chekuremara. Iwo maviri makuru subtypes ekurohwa ischemic sitiroko (accounting ye68%) uye hemorrhagic sitiroko (32%). Pasinei nekusiyana kwavo pathophysiology mumatanho ekutanga, zvese zvinotungamira mukuderedzwa kweropa uye inotevera cerebral ischemia panguva ye subacute uye isingaperi zvikamu.
Ischemic Stroke
Ischemic sitiroko (AIS) inoratidzwa nekukasira kuvharika kwemudziyo weropa, zvichikonzera kukanganisa ischemic kune yakabatwa nzvimbo. Muchikamu cheacute, iyi yekutanga hypoxic nharaunda inokonzeresa kudonha kweexcitotoxicity, oxidative kusagadzikana, uye activation ye microglia, zvichikonzera kufa kwakapararira neuronal. Munguva ye subacute phase, kuburitswa kwe cytokines, chemokines, uye matrix metalloproteinases (MMPs) inogona kubatsira kune neuroinflammation. Zvinonyanya kukosha, mazinga akakwirira eMMPs anowedzera kupera kweropa-brain barrier (BBB), kubvumira leukocyte kutama munzvimbo yakavharwa, kuwedzera basa rekuputika.
Iyezvino Kurapa Ischemic Stroke
Mishonga yekutanga inoshanda yeAIS inosanganisira thrombolysis uye thrombectomy. Intravenous thrombolysis inogona kubatsira varwere mukati meawa 4.5, uko kurapwa kwekutanga kunoshandura kuita zvakanakira. Kuenzaniswa nethrombolysis, mechanical thrombectomy ine hwindo rekurapa rakakura. Mukuwedzera, kwete-pharmacological, kwete-invasive marapirwo akadaioxygen therapy, acupuncture, uye kukurudzirwa kwemagetsi zviri kuwedzera kusimba semishonga yekubatanidza kune nzira dzakajairika.
Izvo Zvinokosha zveHyperbaric Oxygen Therapy (HBOT)
Pakumanikidzwa kwegungwa (1 ATA = 101.3 kPa), mweya watinofema unoita 21% oksijeni. Pasi pemamiriro ehupenyu, chikamu cheokisijeni yakanyungudika muplasma ishoma, chete inenge 0.29 mL (0.3%) pa100 mL yeropa. Pasi pemamiriro ezvinhu e-hyperbaric, kufema 100% okisijeni kunowedzera mazinga eokisijeni akaparara muplasma zvakanyanya-kusvika ku3.26% pa 1.5 ATA uye 5.6% pa 2.5 ATA. Naizvozvo, HBOT ine chinangwa chekusimudzira chikamu ichi cheokisijeni yakanyungudika, zvinobudirirakuwedzera tishu okisijeni kutenderera munzvimbo dze ischemic. Pakudzvinyirirwa kwepamusoro, okisijeni inopararira zviri nyore kupinda muzvikamu zve hypoxic, ichisvika kureba kwekupararira zvinhambwe zvichienzaniswa neyakajairwa mumhepo.
Parizvino, HBOT yakaona kushandiswa kwakapararira kune ese ari maviri ischemic uye hemorrhagic sitiroko. Zvidzidzo zvinoratidza kuti HBOT inopa neuroprotective mhedzisiro kuburikidza neakawanda akaomarara mamorekuru, biochemical, uye hemodynamic nzira, kusanganisira:
1. Kuwedzera arterial oxygen partial pressure, kunatsiridza kuendeswa kweokisijeni kuuropi tishu.
2. Kugadzikana kweBBB, kuderedza edema yeuropi.
3. Kuwedzeredzwa kwehuropimicrocirculation, kunatsiridza uropi metabolism uye kugadzirwa kwesimba uchichengetedza cellular ion homeostasis.
4. Kudzorwa kwecerebral blood flow kuderedza intracranial pressure uye kuderedza kuzvimba kweuropi.
5. Attenuation yeurouroinflammation post-stroke.
6. Kudzvinyirirwa kweapoptosis uye necrosiskutevera sitiroko.
7. Kuderedza kushungurudzika kweoxidative uye inhibition ye reperfusion kukuvara, yakakosha mustroke pathophysiology.
8. Tsvakurudzo inoratidza kuti HBOT inogona kuderedza vasospasm inotevera aneurysmal subarachnoid hemorrhage (SAH).
9. Uchapupu hunotsigirawo kubatsirwa kweHBOT mukusimudzira neurogenesis uye angiogenesis.
Mhedziso
Hyperbaric oxygen therapy inopa nzira inovimbisa yekurapa sitiroko. Sezvo isu tichiramba tichiburitsa kuomarara kwekupora kwesitiroko, kumwe kuferefeta kuchave kwakakosha kunatsiridza manzwisisiro edu enguva, dosi, uye nzira dzeHBOT.
Muchidimbu, sezvatinoongorora mabhenefiti e hyperbaric okisijeni kurapwa kwesitiroko, zvinova pachena kuti kushandisa kurapa uku kune mukana wekuchinja nzira yatinotarisira nayo ischemic sitiroko, tichipa tariro kune avo vanobatwa nehupenyu huno chinja mamiriro.
Kana iwe uchifarira kuongorora hyperbaric okisijeni kurapa senge ingangoita kurapwa kwekupora sitiroko, tinokukoka iwe kuti ushanyire webhusaiti yedu kuti udzidze zvakawanda nezve yedu yepamusoro hyperbaric oxygen chambers. Nemhando dzakasiyana-siyana dzakagadzirirwa kushandiswa kwese kumba uye nehunyanzvi, MACY-PAN inopa mhinduro dzinounza yemhando yepamusoro, yakanangwa okisijeni kurapwa kutsigira hutano hwako uye kupora rwendo.
Ziva zvigadzirwa zvedu uye maitiro avanogona kusimudzira kugara zvakanaka kwako pawww.hbotmacypan.com.
Nguva yekutumira: Feb-18-2025