Mukurapa kwemazuva ano, mishonga inorwisa mabhakitiriya yaratidza kuva imwe yenzira dzakakosha zvikuru, ichideredza zvakanyanya kuwanda kwezvirwere zvinokonzerwa nehutachiona. Kukwanisa kwayo kushandura mhedzisiro yezvirwere zvinokonzerwa nehutachiona kwakawedzera hupenyu hwevarwere vasingaverengeki. Mishonga inorwisa mabhakitiriya inokosha mukurapa kwakaoma, kusanganisira kuvhiyiwa, kuiswa kwezvimiti, kuisirwa mishonga, uye chemotherapy. Zvisinei, kubuda kwezvirwere zvisingaurayi mabhakitiriya kwave kuri kunetseka kuri kukura, zvichideredza kushanda kwemishonga iyi nekufamba kwenguva. Mienzaniso yekusarara kwemishonga inorwisa mabhakitiriya yakanyorwa mumhando dzese dzemishonga inorwisa mabhakitiriya sezvo kushanduka kwehutachiona kunoitika. Kumanikidzwa kwekusarudza kunoitwa nemishonga inorwisa mabhakitiriya kwakabatsira mukuwedzera kwemarudzi asingaurayi, zvichikonzera dambudziko guru kuhutano hwepasi rose.
Kuti tirwise dambudziko guru rekusagona kurwisa mabhakitiriya, zvakakosha kushandisa nzira dzinoshanda dzekudzivirira hutachiona dzinoderedza kupararira kwehutachiona husingaurayiwi nemishonga inorwisa mabhakitiriya, pamwe nekuderedza kushandiswa kwemishonga inorwisa mabhakitiriya. Uyezve, pane kudiwa kukuru kwenzira dzekurapa dzimwe nzira. Kurapa neHyperbaric Oxygen Therapy (HBOT) kwave kuri nzira inovimbisa munyaya iyi, inosanganisira kufema oxygen 100% padanho rakati repamusoro kwenguva yakati. HBOT, iyo iri kurapwa kwekutanga kana kwekuwedzera kwehutachiona, inogona kupa tariro itsva mukurapa hutachiona hunokonzerwa nehutachiona husingaurayiwi nemishonga inorwisa mabhakitiriya.
Kurapa uku kuri kushandiswa zvakanyanya senzira yekutanga kana imwe nzira yekurapa zvirwere zvakasiyana-siyana, zvinosanganisira kuzvimba, chepfu yecarbon monoxide, maronda asingaperi, zvirwere zve ischemic, uye hutachiona. Kushandiswa kweHBOT mukurapa hutachiona kwakakura, zvichipa mabhenefiti akakosha kuvarwere.
Kushandiswa kweKliniki kweHyperbaric Oxygen Therapy muUtachiona
Humbowo huripo hunotsigira zvakasimba kushandiswa kweHBOT, senzira yekurapa yakazvimirira uye yekuwedzera, zvichipa mabhenefiti makuru kuvarwere vane hutachiona. Munguva yeHBOT, kumanikidzwa kweokisijeni muropa kunogona kukwira kusvika 2000 mmHg, uye kukwira kweokisijeni mumasero kunogona kukwidza mwero weokisijeni mumasero kusvika 500 mmHg. Mhedzisiro yakadaro inonyanya kukosha mukusimudzira kuporeswa kwemhinduro dzekuzvimba uye kukanganiswa kweropa mumasero kunoonekwa munzvimbo dzisina kugadzikana, pamwe nekutarisira chirwere chemudumbu.
HBOT inogonawo kukanganisa mamiriro ezvinhu anoenderana nehurongwa hwemuviri hwekudzivirira muviri. Tsvagiridzo inoratidza kuti HBOT inogona kudzvinyirira zvirwere zve autoimmune uye mhinduro dzemuviri dzinokonzereswa ne antigen, zvichibatsira kuchengetedza kushivirira kwe graft nekuderedza kutenderera kwe lymphocytes ne leukocytes ukuwo ichigadzirisa mhinduro dzemuviri. Pamusoro pezvo, HBOTinotsigira kuporesamuzvironda zveganda zvinogara kwenguva refu kuburikidza nekukurudzira angiogenesis, nzira yakakosha yekuvandudza kupora. Kurapa uku kunokurudzirawo kuumbwa kwecollagen matrix, chikamu chakakosha mukupora kwemaronda.
Kunyatsotarisirwa kunofanira kupihwa kune mamwe hutachiona, kunyanya hutachiona hwakadzika uye hwakaoma kurapa hwakadai se necrotizing fasciitis, osteomyelitis, hutachiona hwemapfupa akapfava kwenguva refu, uye infectious endocarditis. Imwe yenzira dzinonyanya kushandiswa pakurapa dzeHBOT ndeyehutachiona hwemapfupa akapfava neganda uye osteomyelitis ine chekuita nekudzikira kweoxygen mumuviri iyo inowanzo kukonzerwa nemabhakitiriya asina simba kana anodzivirira muviri.
1. Zvirwere zveTsoka zveShuga
Tsoka rine chirwere cheshugaMaronda emudumbu ndiwo dambudziko rinowanzoitika pakati pevarwere vane chirwere cheshuga, richibata vanhu vanosvika 25% vevanhu ava. Utachiona hunowanzoonekwa mumaronda aya (zvichikonzera 40%-80% yezviitiko) uye hunokonzera kuwedzera kwezvirwere nerufu. Utachiona hwetsoka dzechirwere cheshuga (DFIs) hunowanzo sanganisira hutachiona hwemabhakitiriya akawanda ane utachiona hwakasiyana-siyana hunowanikwa. Zvinhu zvakasiyana-siyana, zvinosanganisira fibroblast function defects, collagen formation issues, cellular immune systems, uye phagocyte function, zvinogona kukanganisa kupora kwemaronda muvarwere vane chirwere cheshuga. Zvidzidzo zvakasiyana-siyana zvakaratidza kusashanda zvakanaka kweoxygen muganda sechinhu chikuru chinokonzera kuchekwa kwemapfupa ane chekuita neDFIs.
Seimwe yesarudzo dziripo dzekurapa DFI, HBOT inonzi inowedzera zvakanyanya mwero wekupora kwemaronda etsoka ane chirwere cheshuga, zvichizoderedza kudiwa kwekuchekwa kwemakumbo uye kuvhiyiwa kwakaoma. Hazvingoderedzi chete kukosha kwemabasa anotora nzvimbo yakawanda, akadai sekuvhiyiwa kweflap uye grafting yeganda, asiwo zvinoderedza mitengo uye migumisiro mishoma zvichienzaniswa nesarudzo dzekuvhiya. Ongororo yakaitwa naChen et al. yakaratidza kuti zvidzidzo zvinopfuura gumi zveHBOT zvakaita kuti huwandu hwekupora kwemaronda huve nani ne78.3% muvarwere vane chirwere cheshuga.
2. Kuuraya Utachiona Hwenyama Yakapfava
Utachiona hwematumbu akapfava hunouraya utachiona (NSTIs) hunowanzova nemabhakitiriya akawanda, hunowanzo konzerwa nekusanganiswa kwehutachiona hwemabhakitiriya eaerobic neanaerobic uye hunowanzo batanidzwa nekugadzirwa kwegasi. Kunyange zvazvo NSTI dzisingawanzoitiki, dzinopa huwandu hwakawanda hwerufu nekuda kwekufambira mberi kwadzo nekukurumidza. Kuongororwa nekurapwa panguva yakakodzera uye kwakakodzera ndizvo zvakakosha kuti uwane mhedzisiro yakanaka, uye HBOT yakakurudzirwa senzira yekuwedzera yekurapa NSTIs. Kunyangwe paine gakava pamusoro pekushandiswa kweHBOT muNSTIs nekuda kwekushaikwa kwezvidzidzo zvinotarisirwa,humbowo hunoratidza kuti zvinogona kunge zvakabatana nekuvandudzika kwehuwandu hwekupona uye kuchengetedzwa kwenhengo dzemuviri muvarwere veNSTIOngororo yakaitwa kare yakaratidza kudzikira kukuru kwehuwandu hwevakafa pakati pevarwere veNSTI vanowana HBOT.
1.3 Utachiona Hwenzvimbo Yekuvhiyiwa
MaSSI anogona kupatsanurwa zvichienderana nenzvimbo yehutachiona uye anogona kubva muzvirwere zvakasiyana-siyana, kusanganisira mabhakitiriya e aerobic uye anaerobic. Pasinei nekufambira mberi mumatanho ekudzivirira hutachiona, akadai senzira dzekubvisa utachiona, kushandiswa kwemishonga inorwisa mabhakitiriya yekudzivirira, uye kuwedzerwa kwemishonga yekuvhiya, maSSI achiri dambudziko risingaperi.
Imwe ongororo yakakosha yakaongorora kushanda kweHBOT mukudzivirira maSSI akadzika mukuvhiyiwa kweneuromuscular scoliosis. HBOT isati yavhiyiwa inogona kuderedza zvakanyanya kuwanda kwemaSSI uye kuita kuti ronda rirasikirwe. Kurapa uku kusingapindi mumuviri kunogadzira nzvimbo iyo huwandu hweokisijeni mumatishu eronda hunokwira, izvo zvave zvichibatanidzwa nekuuraya oxidative kurwisa hutachiona. Pamusoro pezvo, inogadzirisa kudzikira kwehuwandu hweropa neokisijeni zvinobatsira mukukura kweSSIs. Kunze kwedzimwe nzira dzekudzivirira hutachiona, HBOT yakakurudzirwa kunyanya kune maoparesheni akachena akadai sekurapa kwe colorectal.
1.4 Kupisa
Kutsva kukuvara kunokonzerwa nekupisa kwakanyanya, magetsi, makemikari, kana mwaranzi uye kunogona kukonzera huwandu hwezvirwere zvakanyanya uye huwandu hwerufu. HBOT inobatsira pakurapa kutsva nekuwedzera huwandu hweokisijeni munyama dzakakuvara. Kunyange zvazvo zvidzidzo zvemhuka nezvekiriniki zvichiratidza mhedzisiro dzakasiyana-siyana maererano nekushanda kweHBOT mukurapa kutsva, ongororo yakaitwa nevarwere 125 vakatsva yakaratidza kuti HBOT haina kuratidza kukanganisa kukuru pahuwandu hwevakafa kana huwandu hwevakaitwa maoparesheni asi yakaderedza avhareji yenguva yekupora (mazuva 19.7 zvichienzaniswa nemazuva 43.8). Kubatanidza HBOT nehurongwa hwakakwana hwekutsva kunogona kudzora sepsis muvarwere vakatsva, zvichikonzera nguva pfupi yekupora uye kuderedzwa kwezvinodiwa zvemvura. Zvisinei, tsvakiridzo yakawanda inodiwa kusimbisa basa reHBOT mukugadzirisa kutsva kwakanyanya.
1.5 Osteomyelitis
Osteomyelitis chirwere chinotapukira mumapfupa kana mumwongo wemapfupa chinowanzokonzerwa nehutachiona hwebhakitiriya. Kurapa osteomyelitis kunogona kuva kwakaoma nekuda kwekusakwana kweropa rinosvika kumapfupa uye kushoma kwemishonga inorwisa mabhakitiriya kupinda mumwongo. Osteomyelitis isingaperi inoratidzwa nehutachiona hunoramba huripo, kuzvimba kudiki, uye kuumbwa kwemapfupa anoputika. Osteomyelitis isingaperi inoreva hutachiona hwemapfupa hunoramba huripo kana huchidzoka kunyangwe kurapwa kwakakodzera.
HBOT yakaratidzwa kuti inovandudza zvakanyanya mwero weokisijeni mumapfupa ane hutachiona. Zviitiko zvakawanda zvakatevedzana uye zvidzidzo zveboka zvinoratidza kuti HBOT inowedzera mhedzisiro yekiriniki kune varwere vane osteomyelitis. Inoita sekuti inoshanda kuburikidza nenzira dzakasiyana-siyana, dzinosanganisira kuwedzera mashandiro emetabolism, kudzvinyirira hutachiona hwebhakitiriya, kuwedzera mhedzisiro yemishonga inorwisa mabhakitiriya, kuderedza kuzvimba, uye kukurudzira kuporesa.maitiro. Mushure meHBOT, 60% kusvika 85% yevarwere vane osteomyelitis isingaperi, isingarapiki inoratidza zviratidzo zvekudzikira kwehutachiona.
1.6 Utachiona hwefungus
Pasi rose, vanhu vanodarika mamiriyoni matatu vanotambura nezvirwere zvefungus zvisingaperi kana zvinopararira, zvichikonzera kufa kwevanhu vanodarika 600,000 pagore. Mhedzisiro yekurapwa kwezvirwere zvefungus inowanzo kanganiswa nekuda kwezvinhu zvakaita sekuchinja kwemamiriro emuviri wemuviri, zvirwere zvirimo, uye hunhu hwehutachiona hwehutachiona. HBOT iri kuva sarudzo inokwezva yekurapa muzvirwere zvefungus zvakakomba nekuda kwekuchengetedzeka kwayo uye hunhu hwayo husingapindi. Zvidzidzo zvinoratidza kuti HBOT inogona kushanda pakurwisa zvirwere zvefungus zvakaita seAspergillus neMycobacterium tuberculosis.
HBOT inokurudzira hutachiona hwefungus nekudzivisa kuumbwa kweAspergillus mu biofilm, uye kushanda kwakawedzerwa kunoonekwa mumhando dzisina majini e superoxide dismutase (SOD). Mamiriro ekushaya hutachiona panguva yehutachiona hwefungus anonetsa kuunza mishonga yefungus, zvichiita kuti huwandu hweokisijeni kubva kuHBOT huve rubatsiro runobatsira, kunyangwe tsvakiridzo yakawanda ichidikanwa.
Hunhu hweHBOT hweKurwisa Utachiona
Nzvimbo ine okisijeni yakawanda inogadzirwa neHBOT inotanga shanduko dzemuviri nedzemakemikari dzinokurudzira hunhu hwemabhakitiriya, zvichiita kuti ive mushonga unoshanda wekuwedzera hutachiona. HBOT inoratidza mhedzisiro inoshamisa pakurwisa mabhakitiriya e aerobic uye mabhakitiriya akawanda asina okisi kuburikidza nenzira dzakadai sekushanda zvakananga kwebhakitiriya, kuwedzera mhinduro dzemuviri, uye mhedzisiro inoshanda pamwe chete nemishonga chaiyo inorwisa mabhakitiriya.
2.1 Mhedzisiro Yakananga yeHBOT yeKurwisa Mabhakitiriya
Kurwisa utachiona zvakananga kweHBOT kunonyanya kukonzerwa nekuumbwa kwemhando dzeokisijeni dzinoshanda (ROS), dzinosanganisira superoxide anions, hydrogen peroxide, hydroxyl radicals, uye hydroxyl ions—zvose izvi zvinoitika panguva yekushandiswa kwemasero.
Kudyidzana pakati peO₂ nezvikamu zvemasero kwakakosha pakunzwisisa kuti ROS inoumbwa sei mumasero. Mune mamwe mamiriro ezvinhu anonzi oxidative stress, kuenzana pakati pekuumbwa kweROS nekuora kwayo kunokanganiswa, zvichikonzera kuwedzera kweROS mumasero. Kugadzirwa kwe superoxide (O₂⁻) kunokonzereswa ne superoxide dismutase, iyo inozoshandura O₂⁻ kuita hydrogen peroxide (H₂O₂). Kuchinja uku kunowedzerwa neFenton reaction, iyo inooxidizes Fe²⁺ kugadzira hydroxyl radicals (·OH) uye Fe³⁺, nokudaro zvichitanga kutevedzana kwe redox kunokuvadza kwekuumbwa kweROS uye kukuvara kwemasero.
Mhedzisiro yeROS ine chepfu inotarisa zvikamu zvakakosha zvemasero zvakaita seDNA, RNA, mapuroteni, uye lipids. Zvinonyanya kukosha kuti DNA ndiyo inonyanya kukonzera chepfu inokonzereswa neH₂O₂, sezvo ichikanganisa zvimiro zve deoxyribose uye ichikuvadza zvidimbu zve base. Kukuvadzwa kwemuviri kunokonzerwa neROS kunosvika kuchimiro che helix cheDNA, chinogona kunge chichikonzerwa ne lipid peroxidation inokonzerwa neROS. Izvi zvinoratidza mhedzisiro yakaipa yemazinga eROS akakwira mukati memaitiro e biological.
Chiito cheROS chekurwisa utachiona
ROS inoita basa guru mukudzivirira kukura kwehutachiona, sezvakaratidzwa kuburikidza nekuumbwa kweROS kunokonzerwa neHBOT. Mhedzisiro yeROS ine chepfu inotarisa zvakananga zvinhu zvemasero zvakaita seDNA, mapuroteni, uye mafuta. Kuwanda kwemhando dzeokisijeni inoshanda kunogona kukanganisa zvakananga mafuta, zvichikonzera lipid peroxidation. Maitiro aya anokanganisa kusimba kwemasero uye, nekudaro, mashandiro emareceptor nemapuroteni ane chekuita nemembrane.
Uyezve, mapuroteni, ayo ariwo mamorekuru akakosha eROS, anogadziriswa maoxidative pane akasiyana amino acid residues akadai secysteine, methionine, tyrosine, phenylalanine, uye tryptophan. Semuenzaniso, HBOT yakaratidzwa kuti inokonzera shanduko dzeoxidative mumapuroteni akati wandei muE. coli, kusanganisira elongation factor G neDnaK, nokudaro ichikanganisa mashandiro avo emasero.
Kuvandudza Dziviriro Yemuviri Kuburikidza neHBOT
Hunhu hweHBOT hunodzivirira kuzvimbaZvakanyorwa, zvichiratidza kuti zvakakosha pakuderedza kukuvara kwenyama uye kudzvinyirira kufambira mberi kwehutachiona. HBOT inokanganisa zvakanyanya kuratidzwa kwema cytokines nezvimwe zvinodzora kuzvimba, zvichikanganisa mhinduro yemuviri. Masisitimu akasiyana-siyana ekuyedza akaona shanduko dzakasiyana mukugadzirwa kwemajini uye kugadzirwa kwemapuroteni mushure meHBOT, izvo zvinogona kuwedzera kana kuderedza kukura kwezvinhu nema cytokines.
Munguva yeHBOT, kuwedzera kwemazinga eO₂ kunokonzera mhinduro dzakasiyana-siyana dzemasero, dzakadai sekudzvinyirira kuburitswa kwezvinorwisa kuzvimba uye kukurudzira lymphocyte ne neutrophil apoptosis. Pamwe chete, zviito izvi zvinovandudza mashandiro ekudzivirira utachiona mumuviri, nokudaro zvichiita kuti hutachiona huporeswe.
Uyezve, zvidzidzo zvinoratidza kuti kuwedzera kwemazinga eO₂ panguva yeHBOT kunogona kuderedza kuratidzwa kwema cytokines anokonzera kuzvimba, anosanganisira interferon-gamma (IFN-γ), interleukin-1 (IL-1), uye interleukin-6 (IL-6). Shanduko idzi dzinosanganisirawo kuderedza chiyero chemasero eCD4:CD8 T uye kugadzirisa mamwe ma soluble receptors, zvichizowedzera mazinga einterleukin-10 (IL-10), izvo zvakakosha pakurwisa kuzvimba uye kukurudzira kuporesa.
Mabasa eHBOT ekurwisa utachiona akabatana nemaitiro akaomarara ehupenyu. Superoxide nepressure yakakwira zvakanzi zvinosimudzira kushanda kweHBOT-induced antibacterial uye neutrophil apoptosis. Mushure meHBOT, kuwedzera kwakanyanya kwemazinga eokisijeni kunowedzera kugona kwekuuraya mabhakitiriya ema neutrophils, chinhu chakakosha chemhinduro yekudzivirira muviri. Uyezve, HBOT inodzvinyirira kunamatira kwe neutrophil, uko kunokonzerwa nekubatana kwe β-integrins pama neutrophils nema intercellular adhesion molecules (ICAM) pama endothelial cells. HBOT inodzivisa kushanda kwe neutrophil β-2 integrin (Mac-1, CD11b/CD18) kuburikidza ne nitric oxide (NO)-mediated process, zvichibatsira mukutama kwema neutrophils kunzvimbo yehutachiona.
Kugadziriswa kwakanyatsojeka kwe cytoskeleton kwakakosha kuti ma neutrophils agone kubvisa hutachiona. S-nitrosylation ye actin yakaratidzwa kuti inokurudzira actin polymerization, zvichiita kuti basa re phagocytic rema neutrophils riitike mushure mekurapwa neHBOT risati raitwa. Uyezve, HBOT inokurudzira apoptosis mumasero eT evanhu kuburikidza nenzira dze mitochondrial, nekukurumidzira kufa kwe lymphocyte mushure meHBOT kuchitaurwa. Kuvhara caspase-9—pasina kukanganisa caspase-8—kwaratidza mhedzisiro yeHBOT yekudzivirira muviri.
Migumisiro yeHBOT neAntimicrobial Agents
Mukushandiswa kwekiriniki, HBOT inowanzo shandiswa pamwe chete nemishonga inorwisa utachiona kurwisa hutachiona zvinobudirira. Mamiriro ekupisa zvakanyanya anowanikwa panguva yeHBOT anogona kukanganisa kushanda kwemamwe mishonga inorwisa utachiona. Tsvagiridzo inoratidza kuti mishonga chaiyo inouraya utachiona, yakadai se β-lactams, fluoroquinolones, uye aminoglycosides, haingoshande chete kuburikidza nemaitiro emuviri asiwo inovimba zvishoma nekushandiswa kwebhakitiriya mumuviri. Nokudaro, kuvapo kweokisijeni uye hunhu hwemuviri hwehutachiona hunokosha pakuongorora mhedzisiro yemishonga inorwisa utachiona.
Humbowo hwakakosha hwakaratidza kuti mwero weokisijeni shoma unogona kuwedzera kupokana kwePseudomonas aeruginosa ku piperacillin/tazobactam uye kuti nharaunda ine okisijeni shoma inobatsirawo mukuwedzera kupokana kweEnterobacter cloacae ku azithromycin. Kusiyana neizvi, mamwe mamiriro e hypoxia anogona kuwedzera kupokana kwebhakitiriya kumishonga inorwisa mabhakitiriya ye tetracycline. HBOT inoshanda senzira inobatsira yekurapa nekukurudzira metabolism ye aerobic uye kudzorera oxygen kumatishu ane hutachiona hwe hypoxia, zvichizowedzera kupokana kwehutachiona kumishonga inorwisa mabhakitiriya.
Muzvidzidzo zvepamberi pekiriniki, musanganiswa weHBOT—unopihwa kaviri pazuva kwemaawa masere pa280 kPa—pamwe chete netobramycin (20 mg/kg/zuva) zvakaderedza zvakanyanya huwandu hwebhakitiriya muStaphylococcus aureus infectious endocarditis. Izvi zvinoratidza kugona kweHBOT sekurapa kwekuwedzera. Ongororo dzakaenderera mberi dzakaratidza kuti pasi pe37°C uye 3 ATA pressure kwemaawa mashanu, HBOT yakawedzera zvakanyanya mhedzisiro yeimipenem pakurwisa Pseudomonas aeruginosa ine macrophage. Pamusoro pezvo, maitiro akabatanidzwa eHBOT necephazolin akaonekwa kuti anoshanda zvakanyanya pakurapa Staphylococcus aureus osteomyelitis mumhuka dzemhuka zvichienzaniswa necephazolin chete.
HBOT inowedzerawo zvakanyanya simba rekuuraya mabhakitiriya re ciprofloxacin paPseudomonas aeruginosa biofilms, kunyanya mushure memaminitsi makumi mapfumbamwe ekubatwa nechirwere ichi. Kuwedzerwa uku kunokonzerwa nekuumbwa kwemarudzi e endogenous reactive oxygen (ROS) uye kunoratidza kunzwa kwakanyanya muma peroxidase-defective mutants.
Mumhando dze pleuritis inokonzerwa ne methicillin-resistant Staphylococcus aureus (MRSA), kushanda pamwe chete kwevancomycin, teicoplanin, uye linezolid neHBOT kwakaratidza kushanda kwakawedzera zvakanyanya pakurwisa MRSA. Metronidazole, mushonga unorwisa mabhakitiriya unoshandiswa zvakanyanya mukurapa hutachiona hwakakomba husina simba uye husina simba hwakadai sehutachiona hwetsoka dzechirwere cheshuga (DFIs) uye hutachiona hwenzvimbo yekuvhiyiwa (SSIs), waratidza kushanda kwakakwirira kwehutachiona pasi pemamiriro ekusashanda kwemuviri. Zvidzidzo zveramangwana zvinofanirwa kuongorora mhedzisiro yeHBOT inorwisa mabhakitiriya pamwe chete ne metronidazole mune zvese zviri mukati memuviri uye mukati memuviri.
Kushanda kweHBOT pakurwisa mabhakitiriya anodzivirira utachiona
Nekushanduka uye kupararira kwemarudzi asingaurayi, mishonga inorwisa mabhakitiriya yechivanhu inowanzorasikirwa nesimba rayo nekufamba kwenguva. Uyezve, HBOT inogona kuva yakakosha mukurapa nekudzivirira hutachiona hunokonzerwa nehutachiona husingaurayiwi nemishonga yakawanda, ichibatsira zvikuru kana mishonga inorwisa mabhakitiriya ikatadza. Zvidzidzo zvakawanda zvakashuma migumisiro yakakosha yeHBOT pahutachiona husingaurayiwi nemishonga. Semuenzaniso, musangano weHBOT wemaminitsi makumi mapfumbamwe pa2 ATM wakaderedza zvakanyanya kukura kweMRSA. Pamusoro pezvo, muhuwandu hwemamodheru, HBOT yakawedzera mhedzisiro yemishonga inorwisa mabhakitiriya yakasiyana-siyana kurwisa hutachiona hweMRSA. Mishumo yakasimbisa kuti HBOT inoshanda mukurapa osteomyelitis inokonzerwa neKlebsiella pneumoniae inogadzira OXA-48 pasina kushandisa mishonga inorwisa mabhakitiriya.
Muchidimbu, kurapwa neokisijeni ine hyperbaric kunomiririra nzira dzakasiyana-siyana dzekudzora hutachiona, zvichiwedzera simba rekudzivirira muviri ukuwo zvichiwedzera kushanda kwemishonga inorwisa mabhakitiriya iripo. Nekutsvaga kwakakwana nekuvandudzwa, ine mukana wekuderedza migumisiro yekusagona kurwisa mabhakitiriya, ichipa tariro muhondo iri kuenderera mberi yekurwisa hutachiona hwemabhakitiriya.
Nguva yekutumira: Kukadzi-28-2025