Neurodegenerative zvirwere(NDDs) inoratidzwa nekurasikirwa kunofambira mberi kana kunoramba kuripo kweavo vanotambura neuronal vanhu mukati mehuropi kana musana. Kurongeka kweNDDs kunogona kuenderana nemhando dzakasiyana-siyana, kusanganisira kugoverwa kweanatomical neurodegeneration (yakadai se extrapyramidal disorders, frontotemporal degeneration, kana spinocerebellar ataxias), primary molecular abnormalities (seamyloid-β, prions, tau, kana α-synuclein), kana kuti chirwere chikuru cheParkintrophicler uye dementia). Zvisinei nekusiyana uku mukurongwa uye zviratidzo zvekuratidzira, matambudziko akadai seParkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS), uye Chirwere cheAlzheimer (AD) anogovera maitiro akajairika anotungamira mukusashanda zvakanaka neuronal uye kufa kwesero.
Nemamiriyoni emamiriyoni pasi rose abatwa neNDD, sangano reWorld Health Organisation rinoti panozosvika gore ra2040, zvirwere izvi zvinenge zvave pachipiri pakufa kwevanhu munyika dzakabudirira. Kunyangwe paine marapiro akasiyana-siyana aripo ekudzikisa uye kugadzirisa zviratidzo zvine chekuita nehurwere chaihwo, nzira dzinoshanda dzekudzikisa kana kurapa kufambira mberi kwemamiriro aya dzinoramba dzisiri nyore. Zvidzidzo zvenguva pfupi yapfuura zvinoratidza shanduko yekurapa paradigms kubva kungoita zviratidzo zvekushandisa kushandisa nzira dzekudzivirira sero kudzivirira kuwedzera kushatisa. Humbowo hwakakura hunoratidza kuti oxidative kusagadzikana uye kuzvimba kunoita basa rakakosha muurourodegeneration, ichiisa nzira idzi sezvinangwa zvakakosha zvekuchengetedza cellular. Mumakore achangopfuura, tsvakurudzo yehwaro uye yekiriniki yakafumura kugona kweHyperbaric Oxygen Therapy (HBOT) mukurapa neurodegenerative zvirwere.
Kunzwisisa Hyperbaric Oxygen Therapy (HBOT)
HBOT inowanzobatanidza kuwedzera kumanikidziro kusvika pamusoro pe 1 absolute atmosphere (ATA) - kumanikidzwa kwepamusoro pegungwa - kwenguva yakareba ye90-120 maminetsi, kazhinji inoda zvirongwa zvakawanda zvichienderana nemamiriro chaiwo ari kurapwa. Kuwedzerwa kwemhepo kudzvinyirirwa kunonatsiridza kuendeswa kweokisijeni kumaseru, izvo zvinosimudzira stem cell kuwanda uye inosimudzira maitiro ekuporesa anoyananiswa nezvimwe zvinhu zvinokura.
Pakutanga, kushandiswa kweHBOT kwakavambwa pamutemo weBoyle-Marriott, uyo unoisa kudzikiswa-kunotsamira kuderedzwa kwemabhuru egasi, pamwe chete nemabhenefiti emazinga akakwira okisijeni mumatishu. Kune huwandu hwehutachiona hunozivikanwa kuti hunobatsira kubva kune hyperoxic state yakagadzirwa neHBOT, kusanganisira necrotic tissues, kukuvara kwemwaranzi, kushungurudzika, kupisa, compartment syndrome, uye gangrene gangrene, pakati pezvimwe zvakanyorwa neUndersea uye Hyperbaric Medical Society. Zvikuru, HBOT yakaratidzawo kushanda senzira yekurapa mumhando dzakasiyana dzekuzvimba kana kutapukira zvirwere, senge colitis uye sepsis. Tichifunga maitiro ayo ekurwisa-kuzvimba uye oxidative, HBOT inopa yakakosha kugona senzira yekurapa yezvirwere zveurourodegenerative.
Preclinical Zvidzidzo zveHyperbaric Oxygen Therapy muNeurodegenerative Diseases: Insights kubva ku3 × Tg Mouse Model.
Imwe yezvidzidzo zvakakurumbirayakatarisana ne3 × Tg mbeva modhi yechirwere cheAlzheimer (AD), iyo yakaratidza kugona kwekurapa kweHBOT mukugadzirisa kushomeka kwenjere. Tsvakurudzo yaisanganisira 17-mwedzi-yemakore emurume 3 × Tg mbeva zvichienzaniswa ne14-mwedzi-yekuzvarwa murume C57BL/6 mice inoshanda sekutonga. Chidzidzo chacho chakaratidza kuti HBOT haina kungovandudza ruzivo rwekuziva chete asiwo yakaderedza zvakanyanya kuzvimba, plaque load, uye Tau phosphorylation-maitiro anokosha ane chokuita neAD pathology.
Izvo zvinodzivirira zvinokonzerwa neHBOT zvakakonzerwa nekuderera kweurouroinflammation. Izvi zvakaratidzwa nekuderedzwa kwe microglial proliferation, astrogliosis, uye secretion ye pro-inflammatory cytokines. Izvi zvakawanikwa zvinosimbisa basa rehuviri reHBOT mukusimudzira kugona kwekuziva uku panguva imwe chete ichideredza neuroinflammatory maitiro ane chekuita nechirwere cheAlzheimer.
Imwe preclinical modhi yakashandiswa 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice kuti iongorore nzira dzekudzivirira dzeHBOT pane neuronal basa uye mota kugona. Mhedzisiro yacho yakaratidza kuti HBOT yakabatsira mukukwidziridza kuita kwemota uye kusimba kwekubata mumakonzo aya, ichienderana nekuwedzera kweiyo mitochondrial biogenesis kusaina, kunyanya kuburikidza nekuitwa kweSIRT-1, PGC-1α, uye TFAM. Izvi zvinoratidzira basa rakakosha remitochondrial basa mune neuroprotective mhedzisiro yeHBOT.
Maitiro eHBOT muNeurodegenerative Zvirwere
Nheyo yepasi pekushandisa HBOT yeNDD iri muhukama pakati pekuderedzwa kweokisijeni uye kukonzeresa kune neurodegenerative shanduko. Hypoxia-inducible factor-1 (HIF-1) inobata basa repakati sechinhu chekunyora chinogonesa kuchinjika kweserura kune yakaderera oksijeni kushushikana uye yakabatanidzwa mune dzakasiyana NDDs dzinosanganisira AD, PD, Huntington's Disease, uye ALS, ichimaka seyakakosha zvinodhaka chinangwa.
Nekuda kwezera iri njodzi yakakosha yeakawanda neurodegenerative kusagadzikana, kuongorora maitiro eHBOT pakuchembera neurobiology kwakakosha. Zvidzidzo zvakaratidza kuti HBOT inogona kuvandudza kushaikwa kwekuziva kwakabatana nezera muzvidzidzo zvevakuru vane hutano.Pamusoro pezvo, varwere vakura vane kukanganiswa kukuru kwendangariro vakaratidza kuvandudzwa kwekuziva uye kuwedzera kwehuropi kuyerera kweropa zvichitevera kuratidzwa kuHBOT.
1. Mhedzisiro yeHBOT pane Inflammation uye Oxidative Stress
HBOT yakaratidza kugona kuderedza neuroinflammation muvarwere vane huropi hwakanyanya kusagadzikana. Iine simba rekudzikisa pro-inflammatory cytokines (yakadai seIL-1β, IL-12, TNFα, uye IFNγ) ichisimudza anti-inflammatory cytokines (se-IL-10). Vamwe vaongorori vanofungidzira kuti reactive oxygen marudzi (ROS) anogadzirwa neHBOT anoyananisa akati wandei anobatsira ekurapa. Nekuda kweizvozvo, kunze kwekumanikidza-kunoenderana nebubble-kuderedza chiito uye kuwanikwa kwepamusoro tishu okisijeni saturation, mhedzisiro yakanaka yakabatana neHBOT inoenderana nemaitiro emuviri eiyo ROS yakagadzirwa.
2. Migumisiro yeHBOT paApoptosis uye Neuroprotection
Tsvagiridzo yakaratidza kuti HBOT inogona kuderedza hippocampal phosphorylation yep38 mitogen-activated protein kinase (MAPK), yozovandudza cognition uye kuderedza kukuvara kwehippocampal. Zvose zvakamira HBOT uye pamwe chete neGinkgo biloba extract zvakawanikwa kuderedza kutaura kweBax uye basa re caspase-9 / 3, zvichiita kuti kuderera kweapoptosis mazinga mumakonzo anokonzerwa neaβ25-35. Uyezve, imwe ongororo yakaratidza kuti HBOT preconditioning inokonzera kushivirira kurwisa cerebral ischemia, ine nzira dzinosanganisira kuwedzera SIRT1 kutaura, pamwe nekuwedzera B-cell lymphoma 2 (Bcl-2) mazinga uye yakaderedzwa inoshanda caspase-3, ichisimbisa HBOT's neuroprotective uye anti-apoptotic properties.
3. Kufurira kweHBOT paKutenderera uyeNeurogenesis
Kufumura zvidzidzo kuHBOT kwave kwakabatana nemhedzisiro yakawanda pane cranial vascular system, kusanganisira kuwedzera ropa-brain barriers permeability, kukurudzira angiogenesis, uye kuderedza edema. Pamusoro pekupa yakawedzera okisijeni kune tishu, HBOTinokurudzira kugadzirwa kwevascularkuburikidza nekuita zvinyorwa zvinyorwa zvakadai sevascular endothelial growth factor uye nekukurudzira kuwanda kweneural stem masero.
4. Epigenetic Migumisiro yeHBOT
Zvidzidzo zvakaratidza kuti kuratidzwa kwevanhu microvascular endothelial masero (HMEC-1) kune hyperbaric oxygen inogadzirisa zvakanyanya 8,101 majini, kusanganisira zvose zvakagadziriswa uye zvakaderedzwa mazwi, zvichiratidza kuwedzera kwekutaura kwegene kunobatanidza ne antioxidant mhinduro nzira.
Mhedziso
Kushandiswa kweHBOT kwaita nhanho huru nekufamba kwenguva, zvichiratidza kuwanikwa kwayo, kuvimbika, uye kuchengetedzeka mukuita kwekiriniki. Nepo HBOT yakaongororwa senge isiri-label kurapwa kweNDDs uye kumwe kutsvagisa kwakaitwa, pachine kudiwa kwakanyanya kwezvidzidzo zvakaomarara kuti zvigadzirise maitiro eHBOT mukurapa aya mamiriro. Kumwe kutsvagisa kwakakosha kuti uone kwakaringana kurapwa frequency uye kuongorora huwandu hwemhedzisiro inobatsira kune varwere.
Muchidimbu, kupindirana kwe hyperbaric oxygen uye neurodegenerative zvirwere zvinoratidza muganhu unovimbisa mune zvingango kurapa, zvichibvumira kuenderera mberi kwekuongorora uye kusimbiswa mumakiriniki.
Nguva yekutumira: May-16-2025